The home team rode on goals by Andre Schembri (4th minute), L.Z. Chhangte (30th minute) and Nerijus Valskis (40th) to secure victory after two straight draws.
Bartholomew Ogbeche with a strike in the 15th minute had equalized for the Kerala team.
The result sees Chennaiyin leapfrog Blasters into the eighth position while the visitors stretched their winless run to eight matches.
However, the excitement of the first half was not seen in the second as no goals were scored.
To Chennaiyin FC’s credit, the defense held firm amid some threat from the Blasters forwardline and kept the two-goal lead intact.
A goal in the fourth minute by Schembri sent the home fans into raptures as CFC seemed to have found the goal-scoring touch a long barren period at the start of the season.
The early goal injected a bit of confidence into the home side’s game, but they could not hold on to the lead for long.
Blasters equalised in the 14th minute through Ogbeche. An intelligent free-kick routine saw Mario Arques lay the ball off for Ogbeche, who finished with an excellent shot that flew past a hapless Vishal Kaith.
The third goal came when Chhangte got on the end of a long ball from Anirudh Thapa and attempted a lob from distance after seeing Rehenesh rush off his line. However, the ball bounced back off the post and fell for Valskis who shot home.